Silodosin (Rapaflo): Basics, Side Effects & Reviews (2023)

Silodosin (Rapaflo) treats symptoms of an enlarged prostate.

COMMON BRANDS

Rapaflo

DRUG CLASS

Alpha blocker

CONTROLLED SUBSTANCE CLASSIFICATION

Not a controlled medication

GENERIC STATUS

Lower-cost generic available

AVAILABILITY

Prescription only

Reviewed by:

Hope Chang, PharmD, AAHIVP

Allison Barnes, PharmD

Last reviewed on:

July 11, 2020

Advertisement

What is silodosin (Rapaflo)?

How silodosin (Rapaflo) works

Silodosin (Rapaflo) is an alpha-1 blocker. This means it specifically blocks a receptor located on your prostate and bladder to relax those muscles and make it easier for you to urinate.

What is silodosin (Rapaflo) used for?

  • Benign prostatic hyperplasia (BPH)

Silodosin (Rapaflo) dosage forms

Silodosin (Rapaflo): Basics, Side Effects & Reviews (1)

capsule

4mg8mg

Typical dosing for silodosin (Rapaflo)

The typical dose of silodosin (Rapaflo) is 8 mg once daily with a meal.

Frequently asked questions about silodosin (Rapaflo)

Silodosin (Rapaflo): Basics, Side Effects & Reviews (2)

Is silodosin (Rapaflo) the same as Flomax?

Silodosin (Rapaflo) and Flomax (tamsulosin) are both alpha blockers, meaning they work at the same receptors in our bodies. This doesn't mean that they are the same. Silodosin (Rapaflo) might work better for some people, while others do better on Flomax. They also differ in the side effects each person may experience.

Most people in studies saw improvements in their prostate symptoms within the first month of the study. This will change from person to person. Talk to your doctor if you don't have any changes within the first few months of taking silodosin (Rapaflo) daily.

Avoid drinking alcohol, which could make you dizzy while you are taking silodosin (Rapaflo).

No, silodosin (Rapaflo) won't change the size of your prostate. Instead it works by relaxing the muscles around your prostate and bladder.

Talk to your doctor before taking Viagra with silodosin (Rapaflo). This combination can make your blood pressure go too low.

Pros and cons of silodosin (Rapaflo)

Pros

Silodosin (Rapaflo): Basics, Side Effects & Reviews (7)Improves symptoms of BPH (benign prostatic hyperplasia)

Silodosin (Rapaflo): Basics, Side Effects & Reviews (8)Once daily dosing

Silodosin (Rapaflo): Basics, Side Effects & Reviews (9)If it's hard to swallow the capsules, you can open them up and sprinkle them on applesauce

Silodosin (Rapaflo): Basics, Side Effects & Reviews (10)Generic available

Cons

Silodosin (Rapaflo): Basics, Side Effects & Reviews (11)Has a number of side effects related to low blood pressure such as dizziness

Silodosin (Rapaflo): Basics, Side Effects & Reviews (12)Can cause retrograde ejactulation (an orgasm with little or no semen), which might lead to fertlity problems

Silodosin (Rapaflo): Basics, Side Effects & Reviews (13)Might complicate cataract surgery; make sure your eye doctor knows you are taking silodosin (Rapaflo)

Silodosin (Rapaflo): Basics, Side Effects & Reviews (14)Can't be used in people with severe kidney or liver problems

Pharmacist tips for silodosin (Rapaflo)

Silodosin (Rapaflo): Basics, Side Effects & Reviews (15)Always take silodosin (Rapaflo) with a meal. Taking it on an empty stomach can lead to more side effects.

Silodosin (Rapaflo): Basics, Side Effects & Reviews (16)If you have a hard time swallowing the capsule, you can open it up and sprinkle what's inside onto a tablespoon of applesauce. Once sprinkled you should swallow the spoonful immediately without chewing. After this, drink a full glass of water to make sure all the medication has been swallowed.

Silodosin (Rapaflo): Basics, Side Effects & Reviews (17)Avoid using heavy machinery and other activities that require a lot of coordination when you first start this medication. This medication can cause side effects that make these activities more difficult so it's best to wait until you know how this medication affects your body.

Silodosin (Rapaflo): Basics, Side Effects & Reviews (18)Silodosin (Rapaflo) can make people feel dizzy or lightheaded, especially when they go from laying down or sitting to standing. This can be dangerous if the dizziness causes you to fall. When you are standing up, try to hold on to something like a sturdy table to help support your weight and don't stand up too quickly.

Silodosin (Rapaflo): Basics, Side Effects & Reviews (19)There are some medications that can raise the amount of silodosin (Rapaflo) in your body. Make sure you talk to your provider about all the medications you are taking; your provider might need to change the doses of your medications to make sure you are getting the right amount of everything you are prescribed.

Silodosin (Rapaflo): Basics, Side Effects & Reviews (20)

Prices for silodosin (Rapaflo) start at just $24.00 with a GoodRx coupon. They’re fast, easy-to-use and free!

View Coupon Prices

What are the side effects of silodosin (Rapaflo)?

With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.

Silodosin (Rapaflo): Basics, Side Effects & Reviews (21) The following side effects may get better over time as your body gets used to the medication. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time.

Common side effects

  • Retrograde ejaculation (orgasm with less/no semen) (28%)
  • Dizziness (3%)
  • Diarrhea (3%)
  • Low blood pressure (3%)

Other side effects

  • Headache
  • Congestion/runny nose
  • Trouble sleeping
  • Upset stomach

Source: FDA

The following side effects have also been reported:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Chills

cold sweats

confusion

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

Incidence not known

Clay-colored stools

dark urine

fever

headache

hives, itching, rash

loss of appetite

nausea

pinpoint red or purple spots on the skin

skin blisters

stomach pain

unpleasant breath odor

unusual tiredness or weakness

vomiting of blood

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Change or problem with discharge of semen

Less common

Diarrhea

muscle aches

sore throat

stuffy or runny nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What are the risks and warnings for silodosin (Rapaflo)?

Silodosin (Rapaflo) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options

LOW BLOOD PRESSURE

  • Risk factors: Taking other blood pressure medications

Silodosin (Rapaflo) can cause dizziness from your blood pressure going too low. This can happen when you go from sitting to standing. This is usually worse when you first start taking silodosin (Rapaflo) and in some cases this can cause you to lose consciousness. Be extra careful when driving or using heavy machinery when you first start taking this medication.

KIDNEY PROBLEMS

Silodosin (Rapaflo) cannot be used in people with severe kidney problems because the levels of the medication will be too high in your body. For those who have mild-moderate kidney problems, silodosin (Rapaflo) can still be used, but the dose will be 4 mg daily instead of 8 mg.

LIVER PROBLEMS

Silodosin (Rapaflo) cannot be used by people with severe liver problems.

DRUG-DRUG INTERACTIONS

  • Risk factors: Taking other medications

Silodosin (Rapaflo) interacts with a number of medications. There are some medications that can slow down the breakdown of silodosin (Rapaflo) and cause the levels to go too high in your body. There are other medications that having overlapping side effects and can make the side effects worse. Make sure you talk to your doctors and pharmacists about all the medications you are taking. They might need to change the doses of the medications you are taking.

PROSTATE CANCER

Many of the symptoms of prostate cancer and enlarged prostate overlap. Your doctor will examine you for prostate cancer to rule it out before treating you for BPH.

FLOPPY IRIS SYNDROME

  • Risk factors: Cataracts surgery

Tell your eye doctor if you are or have ever taken silodosin (Rapaflo) in the past. Although rare, some people have experienced this rare eye condition during cataract surgery.

Interactions between silodosin (Rapaflo) and other medications

Silodosin (Rapaflo) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with silodosin (Rapaflo). Please note that only the generic name of each medication is listed below.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Atazanavir
  • Boceprevir
  • Clarithromycin
  • Cobicistat
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Nefazodone
  • Nelfinavir
  • Ritonavir
  • Saquinavir
  • Telithromycin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfuzosin
  • Bunazosin
  • Cyclosporine
  • Dapiprazole
  • Doxazosin
  • Moxisylyte
  • Phenoxybenzamine
  • Phentolamine
  • Prazosin
  • Simeprevir
  • Tamsulosin
  • Terazosin
  • Tolazoline
  • Trimazosin
  • Urapidil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Sildenafil
  • Tadalafil
  • Vardenafil

How much does silodosin (Rapaflo) cost?

Silodosin (Rapaflo) is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.

Lowest GoodRx Price
Rapaflo (brand)

$271.79

Lowest GoodRx Price
silodosin (generic)

$24.00

Pricing based on most commonly-filled versions: 30 capsules of silodosin 8mg

What are alternatives to silodosin (Rapaflo)?

There are a number of medications that your doctor can prescribe in place of silodosin (Rapaflo). Compare a few possible alternatives below.

Silodosin (Rapaflo)

Drug Class:Alpha blocker

Used for:

  • Benign prostatic hyperplasia (BPH)

$24.00

lowest GoodRx price

View Prices

Finasteride (Proscar)

Drug Class:5-alpha reductase inhibitor

Used for:

Enlarged prostate (BPH - benign prostatic hyperplasia)

$14.47

lowest GoodRx price

View Prices

Get savings updates for silodosin (Rapaflo)

Receive price alerts, news, and other messages from GoodRx about silodosin (Rapaflo) and other healthcare topics and relevant savings offers.

By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

Top Articles
Latest Posts
Article information

Author: Jerrold Considine

Last Updated: 12/11/2022

Views: 5878

Rating: 4.8 / 5 (58 voted)

Reviews: 89% of readers found this page helpful

Author information

Name: Jerrold Considine

Birthday: 1993-11-03

Address: Suite 447 3463 Marybelle Circles, New Marlin, AL 20765

Phone: +5816749283868

Job: Sales Executive

Hobby: Air sports, Sand art, Electronics, LARPing, Baseball, Book restoration, Puzzles

Introduction: My name is Jerrold Considine, I am a combative, cheerful, encouraging, happy, enthusiastic, funny, kind person who loves writing and wants to share my knowledge and understanding with you.